ABSTRACT
We experienced a case of adult T cell leukemia/lymphoma (ATLL) in a 48-year-old Korean female, who has never been abroad since birth and no history of blood transfusion. The patient had hypercalcemia and multiple lymphadenopathy. Histopathologic study of left cervical lymph node (LN) and bone marrow (BM) revealed that infiltrates of malignant lymphoid cells were composed of small, medium and large cells with pleomorphic nuclei. Smears of peripheral blood (PB) showed lymphopenia (16%) with the appearance of a few atypical lymphoid cells (less than 2%), but not the typical clover leaf cells seen in ATLL. Immunophenotypic study of LN and BM revealed T cell phenotype. PB showed increased CD4+ T cell (T(H), CD3/CD4+, 57%) and decreased CD8+ T cell counts (T(S), CD3/CD8+, 6.7%). The sera of the patient and her family were reactive for HTLV-I antibody. The specific sequences of pol, env, and tax of HTLV-I DNA were detected in the lymphoma cells and peripheral blood mononuclear cells (PBMC) using polymerase chain reaction. Ultrastructural examination of PBMC confirmed numerous type c virus particles in extracellular space. This case was an acute type of ATLL without overt leukemic features in PB. Despite chemotherapy and intensive conservative treatment, she died 3 months after admission.
Subject(s)
Female , Humans , Biopsy , Bone Marrow/pathology , DNA, Viral/analysis , Fatal Outcome , Flow Cytometry , Gene Products, env/genetics , Gene Products, pol/genetics , Gene Products, tax/genetics , Deltaretrovirus Infections/pathology , Human T-lymphotropic virus 1 , Hypercalcemia/virology , Hypercalcemia/pathology , Immunophenotyping , Korea , Leukemia, T-Cell/virology , Leukemia, T-Cell/pathology , Leukemia, T-Cell/immunology , Lymph Nodes/pathology , Lymphopenia/virology , Lymphopenia/pathology , Lymphopenia/immunology , Microscopy, Electron , Middle Aged , T-Lymphocytes/virology , T-Lymphocytes/ultrastructure , T-Lymphocytes/pathologyABSTRACT
The aim of this study was to identify the factors which may predict the occurrence of spontaneous bacterial peritonitis [SBP] complication. Two groups of cirrhotic patients with ascites were included in the study: A group who had never developed SBP and a group who had been successfully treated from this complication. The liver profile, the immunological status and the local ascitic factors were assessed in both groups. The group who had suffered from SBP showed significantly higher levels of serum bilirubin; while the serum albumin, prothrombin activity, T-lymphocytic count, serum and ascitic C3 and ascitic fluid protein and IgC were significantly lower than in the group who had never suffered SBP
Subject(s)
Humans , Male , Female , Liver Cirrhosis/complications , Ascites , Liver/physiopathology , Lymphopenia/pathology , Ascitic Fluid/chemistryABSTRACT
Se determinaron los valores avsolutos de la sdistintas poblaciones leucocitarias periféricas en ratones BALB/c normales y esplenectomizados (XB), desafiados con Sarcoma 180 sólido (S180s) y ascítico (S180a), inoculados por vías subcutánea e intraperitoneal, respectivamente. Las evaluaciones fueron realizadas al 8-, 15- y 25- día de crecimiento tumoral. Se observó: 1) leucocitosis en todos los grupos; 2) disminución del número de linfocitos al 15- y 25- día y disminución de monocitos al día 25-, en el grupo con S180s; 3) en el grupo XB, un incremento de todas las poblaciones leucocitarias, máximo entre el 8- y 15- día, valores que tendieron a normalizarse en el día 25-, en el grupo XB inoculado con S18s, neutrofilia, linfocitosis y monocitosis hasta el día 25-; 4) los valores máximos de neutrofilia correpsondieron al grupo S180a con 1905% de incremento en el día 15-, mientras que las cifras mayores de linfocitos y monocitos fueron observadas en el brupo XB inoculado con S180s en el día 15- con incrementos de 387% y 589% respectivamente, y 5) el aumento de neutrófilos fue constante en todos los grupos, observándose además altereaciones particulares en cada grupo